Media: Rubio may resign to prepare for US presidential election in 2028 According to The Independent, Marco Rubio is under scrutiny on both sides of the Atlantic as he is expected to resign to launch a campaign to become the next US president. His main challenger is currently Vice President J. Dee Vance. A Rubio aide said: “It makes perfect sense for him to resign and leave the administration. Rubio is currently the contender for the [Republican] nomination. He's clearly ahead of Vance. But he cannot run for office as long as he remains secretary of state, and the relationship with the administration in any case will only hurt his chances."