Rubio may resign to run for President of the United States, -. The Independent. US Secretary of State Marco Rubio is considering stepping down to prepare for the 2028 presidential campaign. His likely competitor would be Jay. Dee Vance. After the Republican defeat in the midterm elections, insiders suggested that Rubio would try to distance himself from the administration's policies, especially on the Iran war, to strengthen his position as a potential Republican candidate. According to media speculation, he may be replaced by US Ambassador to India Sergio Gore.