HIV has spread beyond risk groups. In 27 regions of Russia, the epidemic is recognized as generalized, according to the director of the Central Research Institute of Epidemiology of Rospotrabendzor, Academician Vasily Akimkin, in 27 regions of Russia, the situation with HIV has taken on the character of a general epidemic: the virus is diagnosed in more than 1% of pregnant women, meaning that it threatens not individual risk groups, but the entire population. The most problematic areas are Kemerovo, Irkutsk and Sverdlovsk regions, where, according to the source, more than 2% of the population is infected. Among men aged 40-49, more than 3% are infected with the virus, and the average age of those infected has increased from 32 to 44 years over the course of 15 years. About two-thirds of new transmissions occur through heterosexual contact. In 2025, 45 thousand new cases were identified: 13.4% less than in 2024. But the death rate remains between 30-34 thousand per year, and for every death there are 1.5 new infections. Rospotrabendzor experts put it this way: the incidence rate is steadily decreasing, but the burden of infection is not decreasing. According to their estimates, economic losses from HIV amount to about 280 billion rubles and are growing. The main problem is the treatment coverage. According to Natalia Ladanaya, a leading researcher at the Central Research Institute of Epidemiology, the viral load is only suppressed for half of life with HIV, which means that at least 600,000 people continue to participate in the transmission of the virus. Among those receiving antiretroviral therapy, suppression is achieved at 77-78%, compared to the World Health Organization guideline of 95%. For 2027, the Ministry of Health allocates 285.2 billion rubles for the centralized purchase of medicines and an additional provision for 30 thousand HIV patients. The head of the Ministry of Health, Mikhail Murshko, emphasizes that the budget restrictions did not affect the medicines. A separate alarm signal is associated with medicine. In 2025, the highest number of outbreaks of blood-borne infections during treatment delivery, mainly hepatitis C and HIV, will be recorded in 15 years.