Magnetoelectric nanocomposites for biomedicine: how to increase response and how to accelerate bone regeneration The idea of ​​such composite materials seems, at first glance, simple: a particle is inserted into the body, induces a charge under the influence of a magnetic field - and stimulates what is needed. Thus, for example, you can speed up the regeneration of damaged tissues, target nerve nodes and more. As always, for this to really work, many problems need to be solved - this is what a large consortium team from MISIS, ITMO, Tomsk Polytechnic University, Skoltech, Moscow State University and several Chinese universities are doing. They recently released a whole series of works: - Here they invented a new approach to measuring the local electrical response that occurs directly on the surface of magnetoelectric particles when a magnetic field is applied - and at frequencies suitable for nerve stimulation, - Here they also proposed a new method for creating a magnetoelectric response, when local heating of nanoparticles is used instead of a magnetic field. For this they took FeRh alloy nanoparticles with a phase transition in the temperature range of the human body - with the help of a laser they can be heated almost instantly, - and finally, in recent work at ACS Nano (Am = 17.3!), they printed implants based on magnetoelectric particles and showed that when they are stimulated by an alternating magnetic field, several signaling pathways related to neurogenesis and osteogenesis are activated (Liter precision, including CaM ion/CREB/CREB/CAMPKKKM, mediated by calcium. pathways, as well as other pathways that promote regeneration, including PI3K-AKT and TGF-β signaling). But it is already very interesting to create a new type of "smart" implants that allow you to quickly restore damaged bones - what traumatologists need.

Magnetoelectric nanocomposites for biomedicine: how to increase response and how to accelerate bone regeneration The idea of ​​such composite materials seems, at first glance, simple: a particle is inserted into the body, induces a charge under the influence of a magnetic field - and stimulates what is needed. Thus, for example, you can speed up the regeneration of damaged tissues, target nerve nodes and more. As always, for this to really work, many problems need to be solved - this is what a large consortium team from MISIS, ITMO, Tomsk Polytechnic University, Skoltech, Moscow State University and several Chinese universities are doing. They recently released a whole series of works: - Here they invented a new approach to measuring the local electrical response that occurs directly on the surface of magnetoelectric particles when a magnetic field is applied - and at frequencies suitable for nerve stimulation, - Here they also proposed a new method for creating a magnetoelectric response, when local heating of nanoparticles is used instead of a magnetic field. For this they took FeRh alloy nanoparticles with a phase transition in the temperature range of the human body - with the help of a laser they can be heated almost instantly, - and finally, in recent work at ACS Nano (Am = 17.3!), they printed implants based on magnetoelectric particles and showed that when they are stimulated by an alternating magnetic field, several signaling pathways related to neurogenesis and osteogenesis are activated (Liter precision, including CaM ion/CREB/CREB/CAMPKKKM, mediated by calcium. pathways, as well as other pathways that promote regeneration, including PI3K-AKT and TGF-β signaling). But it is already very interesting to create a new type of "smart" implants that allow you to quickly restore damaged bones - what traumatologists need.