Every cell has the same DNA. Google’s new artificial intelligence predicts which cell mutations affect AlphaGenome 2 from Google DeepMind, showing how a single DNA change plays out in a specific type of cell, from heart muscle to immune cells. The first version only saw whole tissues, so it could miss versions that work in one cell type. On a map of 28 immune cell types, the new model found almost twice as many versions that alter gene activity, 30% versus 16% for the source. In a computer test it also replicated a recent finding: a version behind inflammatory bowel disease that upregulates one gene only in certain immune cells, leaving other cells largely unaffected. Scientists can feed it from a few dozen of their own cells, such as immune cells after vaccination, without training. AlphaGenome 2 is now available for non‑commercial research. DeepMind says it is not approved for clinical use or diagnosis. Terms:

Every cell has the same DNA. Google’s new artificial intelligence predicts which cell mutations affect AlphaGenome 2 from Google DeepMind, showing how a single DNA change plays out in a specific type of cell, from heart muscle to immune cells. The first version only saw whole tissues, so it could miss versions that work in one cell type. On a map of 28 immune cell types, the new model found almost twice as many versions that alter gene activity, 30% versus 16% for the source. In a computer test it also replicated a recent finding: a version behind inflammatory bowel disease that upregulates one gene only in certain immune cells, leaving other cells largely unaffected. Scientists can feed it from a few dozen of their own cells, such as immune cells after vaccination, without training. AlphaGenome 2 is now available for non‑commercial research. DeepMind says it is not approved for clinical use or diagnosis. Terms: