Autoimmune diseases in parents have been linked to an increased risk of developing type 1 diabetes in children Swedish researchers led by Mo Xingbo from the Karolinska Institute have shown that autoimmune diseases in parents increase the risk of developing type 1 diabetes in children. When the mother was ill, the risk increased by 57% on average, and the father by 51%. Children are becoming more and more sick with type 1 diabetes; In addition to genetics, a family history of autoimmune disease is important, but there has been little evidence of such an association. Scientists conducted a population-based cohort study using nationwide Swedish registries, and examined autoimmune pathologies in various organ systems. The study included 1,455,645 children, 88,368 of whom suffered from a maternal autoimmune disease. During a median of 15.3 years of follow-up, there were 10,273 cases of diabetes. The incidence was higher in children of mothers with autoimmune diseases, and was highest when both parents were affected. After adjustment for parental diabetes and first cousin analysis, the relationship was weakened but remained significant. Rheumatoid arthritis and autoimmune thyroiditis increased the risk regardless of who had the disease; The mother also has celiac disease, vitiligo, vasculitis and spondylitis, and the father has sarcoidosis. The mother's and father's contributions were roughly equal; Adjustment for smoking, body mass index and family history did not significantly change the relationships. The authors support a multifactorial model of intergenerational transmission of autoimmune diseases; The results can be applied for diabetes risk stratification in children in immunocompromised families. JAMA Pediatrics.

Autoimmune diseases in parents have been linked to an increased risk of developing type 1 diabetes in children Swedish researchers led by Mo Xingbo from the Karolinska Institute have shown that autoimmune diseases in parents increase the risk of developing type 1 diabetes in children. When the mother was ill, the risk increased by 57% on average, and the father by 51%. Children are becoming more and more sick with type 1 diabetes; In addition to genetics, a family history of autoimmune disease is important, but there has been little evidence of such an association. Scientists conducted a population-based cohort study using nationwide Swedish registries, and examined autoimmune pathologies in various organ systems. The study included 1,455,645 children, 88,368 of whom suffered from a maternal autoimmune disease. During a median of 15.3 years of follow-up, there were 10,273 cases of diabetes. The incidence was higher in children of mothers with autoimmune diseases, and was highest when both parents were affected. After adjustment for parental diabetes and first cousin analysis, the relationship was weakened but remained significant. Rheumatoid arthritis and autoimmune thyroiditis increased the risk regardless of who had the disease; The mother also has celiac disease, vitiligo, vasculitis and spondylitis, and the father has sarcoidosis. The mother's and father's contributions were roughly equal; Adjustment for smoking, body mass index and family history did not significantly change the relationships. The authors support a multifactorial model of intergenerational transmission of autoimmune diseases; The results can be applied for diabetes risk stratification in children in immunocompromised families. JAMA Pediatrics.