A combination of two well-known drugs helped delay premature birth. Premature birth is the leading cause of infant mortality worldwide, accounting for approximately 10% of pregnancies. For decades, the drug almost did not receive new pharmacological methods of their prevention. To find a solution, Stanford University researchers created an accurate digital model of pregnant women's immune systems by analyzing hundreds of millions of individual cells. With the help of such virtual copies of immunity, scientists safely tested the effects of many well-known drugs directly on the computer, without risk to expectant mothers. Computer analysis showed that taking low doses of aspirin and lansoprazole synergistically slows down the "training clock" of pregnancy. Usually, towards the end of term, inflammatory signals are activated to prepare the body for childbirth. If this biochemical cascade is activated prematurely, premature birth occurs. According to the new model, the combination of drugs inhibits early inflammation almost 15 times more than aspirin alone. The model also confirmed the protective properties of folic acid, which helps the immune system soften and adapt to pregnancy. Experiments on mice showed that the combination prevented early miscarriages and delayed birth until normal. Because of this, the US Food and Drug Administration has already approved human trials of the combination. Advanced science.

A combination of two well-known drugs helped delay premature birth. Premature birth is the leading cause of infant mortality worldwide, accounting for approximately 10% of pregnancies. For decades, the drug almost did not receive new pharmacological methods of their prevention. To find a solution, Stanford University researchers created an accurate digital model of pregnant women's immune systems by analyzing hundreds of millions of individual cells. With the help of such virtual copies of immunity, scientists safely tested the effects of many well-known drugs directly on the computer, without risk to expectant mothers. Computer analysis showed that taking low doses of aspirin and lansoprazole synergistically slows down the "training clock" of pregnancy. Usually, towards the end of term, inflammatory signals are activated to prepare the body for childbirth. If this biochemical cascade is activated prematurely, premature birth occurs. According to the new model, the combination of drugs inhibits early inflammation almost 15 times more than aspirin alone. The model also confirmed the protective properties of folic acid, which helps the immune system soften and adapt to pregnancy. Experiments on mice showed that the combination prevented early miscarriages and delayed birth until normal. Because of this, the US Food and Drug Administration has already approved human trials of the combination. Advanced science.