Rubio May Resign Trump's 2028 Race Manager US Secretary of State Marco Rubio may resign after Republicans lose control of both houses of Congress in the midterms, according to The Independent and Washington sources. Rubio needs to distance himself from the Iran war to boost his presidential bid against primary challenger J. Dee Vance. Vance links the party's defeat to the conflict. The White House and State Department deny the resignation reports as baseless.